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KMID : 0903520080510020124
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2008 Volume.51 No. 2 p.124 ~ p.128
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in vitro Anticancer Activity and in vivo Chronic Toxicity of Homoharringtonine
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Yoo Gui-Jae
Cho Cheol-Hee
Lee Gun-Soon
Ryoo Jae-Young
Chae Hee-Jeong
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Abstract
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Cell proliferation inhibitory effects of homoharringtonine (HHT), an active drug substance in Cephalotaxus koreana, against blood cancer cell line K562 were evaluated. In addition, in vivo chronic toxicity test with mouse was carried out. When K562 cell line was treated everyday for 9, 6, 3 days, IC50 values of HHT were determined as 0.27, 0.37, and 1.10 mM respectively. The anticancer activity of HHT was comparable to adriamycin, a known anticancer drug compound for blood cancer treatment. in vivo chronic toxicity test of the HHT, the number of red blood cell (RBC) showed no significant difference. From the analysis of the liver-functional enzymes in blood, all of liver damage related enzymes such as glutamate-oxalate-transferase (GOT), glutamate-pyruvatetransferase (GPT), cholesterol (Chol) and alkaline phosphatase (ALP) showed no significant change. However, from the histologic test, a neutrophil of the band type in liver tissue was observed.in vitro Anticancer Activity and in vivo Chronic Toxicity
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KEYWORD
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Anticancer Activity, Chronic Toxicity, Homoharringtonine
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